November 19, 1932


JAMA. 1932;99(21):1791-1792. doi:10.1001/jama.1932.02740730055023

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Report of Cancer Research  The tenth scientific report of the Imperial Cancer Research Fund has just been published.

CHEMOTHERAPY  Dr. R. J. Ludford has investigated the influence of dyestuffs and inorganic colloids on resistance to transplantable tumors. Beneficial results in the treatment of human cancer have been claimed at different times for colloids of copper, iodine, sulphur, selenium, lead and the acid dyestuff isamine blue. Dr. Ludford's experiments failed to show any direct influence on the cancer cell. Large numbers of dyestuffs were injected into tumor-bearing mice without any sign of inhibition of growth. The general results were that when tumors were growing at their maximum rate injections of dyestuffs and colloids in nonlethal doses were without influence on growth. But when the animal was resistant, as indicated by a preliminary growth of the graft followed by regression, dyestuffs and colloids favored growth by their action on the mechanism of

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