November 19, 1932


JAMA. 1932;99(21):1794-1795. doi:10.1001/jama.1932.02740730058026

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Diabetes and the Hypophysis  Drs. Houssay, Biasotti and Rietti recently lectured before the Academia de Medicina of Buenos Aires on the results of experiments on the rôle of the hypophysis in the development of diabetes. In experiments on toads, they found that diabetes does not develop in those animals deprived of the hypophysis when the pancreas is removed. However, if they are treated by the subcutaneous implantation of the anterior lobe of the hypophysis of fishes, birds or mammals, diabetes develops. Dogs deprived of the hypophysis and subjected to the action of an injection of phlorhizin have an elimination of dextrose and nitrogen slower than that of normal dogs and die with hypoglycemia. Dogs deprived of the hypophysis and later on deprived also of the pancreas suffer the development of a diabetes of slow evolution, with long periods of almost complete disappearance of the diabetic symptoms. Many dogs in this

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