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The comparative rarity in North America of echinococcosis, which is quite prevalent in Europe, Australia and South, America, probably prevents practitioners in this country from appreciating the difficulties surrounding early diagnosis. Pinelli has presented in this volume the biologic methods that have been found of diagnostic value. Each method has been evaluated in a sufficient number of cases, and clear, minute details are given for the technic of all tests. These tests can be divided into three classes: 1. Changes in the blood picture. 2. Seroreactions based on the presence in the circulating plasma of products elaborated by the parasitic cyst. In this class are included complement fixation, Abderhalden reaction, tryptic index of serum, and enzymoreaction of Sivori and Rebaudi. 3. Various intradermal and subcutaneous and ophthalmic tests performed with antigenic materials derived from the parasites and hydatid fluid. The author's intradermal reaction with filtered hydatid fluid freed from protein
La diagnosi biologica dell'echinococcosi.. JAMA. 1932;99(21):1804. doi:10.1001/jama.1932.02740730068038