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April 29, 1950


Author Affiliations


From the Department of Obstetrics and Gynecology and the Department of Biochemistry, University of Colorado Medical Center.

JAMA. 1950;142(17):1331-1332. doi:10.1001/jama.1950.02910350001001

With the advent of chemotherapy and later the first of the antibiotics, it became possible to extend the range of treatment of the fetus via placental transfer from the maternal to the fetal circulation. This mode of treatment has been extensively used within the range of organisms affected and has proved highly effective both as a preventive and a curative treatment for the mother and fetus. When, in 1947, Ehrlich and associates succeeded in isolating and later producing synthetically pure crystalline chloramphenicol (chloromycetin®) treatment of another large group of infections was placed on a practical basis.1 The advantages of an orally effective antibiotic the scope of action of which includes most of the infectious agents encountered in obstetric practice, from which no toxic reactions have been reported and which has the potentiality of an inexpensive product are many. The purpose of this study was to determine, if possible, whether

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