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January 18, 1947

MULTIPLE MYELOMAA Review of Eighty-Three Proved Cases

Author Affiliations

Fellow in Medicine, Mayo Foundation; Rochester, Minn.

From the Division of Medicine, Mayo Clinic.

JAMA. 1947;133(3):147-157. doi:10.1001/jama.1947.02880030001001
Abstract

One hundred years ago, in November 1845, Sir James Watson sent a test tube of urine obtained from a 45 year old tradesman to Dr. Henry Bence-Jones with an accompanying note inquiring as to the nature of a strange substance present in that urine. This substance, then called "animal matter," has since become known as Bence-Jones protein.1 MacIntyre2 reported this case in 1850 in the Medico-Chirurgical Transactions.

Dalrymple3 examined and described pathologically two ribs of an affected patient and reported the condition as mollifies ossium in 1846. However, von Rustizky4 is said to have been the first to describe the condition under the title "multiples myelom" in 1873, and Kahler5 is credited with having associated this disease with the occurrence of Bence-Jones protein in the urine.

Since these early reports additions have been made to the literature steadily and at a somewhat increasing rate as

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