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April 29, 1950

Current Comment

JAMA. 1950;142(17):1366. doi:10.1001/jama.1950.02910350036015

POSTPARTUM PLASMA AND RHEUMATOID ARTHRITIS  In 1938 it was reported by Hench1 that the occurrence of pregnancy in patients with rheumatoid arthritis produces a partial or complete remission of symptoms in a high percentage of cases. Following this lead, Granirer2 of the Arthritic Clinic, Queens General Hospital, Jamaica, New York, found that a sustained remission can be produced by administration of a suitable amount of postpartum plasma. The remission is characterized by an improved sense of well-being, a brighter mental outlook, increased appetite, disappearance of joint symptoms, gain in weight, and a restoration to normal of the microcytic anemia and albumin globulin ratio. There were no toxic effects in 320 postpartum plasma transfusions performed in his clinic. The longest remission was 16 weeks and the shortest 3 weeks. At present there is no clear explanation of the ameliorating effect of postpartum plasma.


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