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May 13, 1950

OBSERVATIONS ON THE CLINICAL USE OF VISAMMIN (KHELLIN)

Author Affiliations

Chicago

Sam Ehrlich Memorial Fellow. (Dr. Rosenman) and Dazian Foundation Fellow (Dr. Fishman).; From the Cardiovascular Department, Medical Research Institute, Michael Reese Hospital, Chicago. (The department is supported in part by the Michael Reese Research Foundation).

JAMA. 1950;143(2):160-165. doi:10.1001/jama.1950.02910370010004
Abstract

The plant, Ammi visnaga Lam, known in Arabic as "Khella," grows wild in Arabia, Egypt and Eastern Mediterranean countries.1 Of the three crystalline compounds which have been isolated from the fruit of the plant,2 visammin (also called khellin) has been claimed to have the greatest biologic activity.3 The pharmacology of this compound has been actively investigated4 and has recently been summarized.1 Early investigators5 have demonstrated the ability of visammin to relax smooth muscle in various organs in situ and in isolated structures such as the ureter. Visammin has been found to be a powerful coronary vasodilator in animals, causing definite increase in coronary blood flow without demonstrable ill effect on the myocardium. It is further characterized by the absence of development of tolerance, by a wide margin of therapeutic safety and by prolonged activity, since its gradual disappearance from blood and tissues results in

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