[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.197.142.219. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
February 6, 1954

NEWER APPROACHES TO THE STUDY OF HEMOPHILIA AND HEMOPHILIOID STATES

Author Affiliations

Chapel Hill, N. C.

From the Department of Pathology, University of North Carolina.; Markle Scholars in Medical Science (Drs. Penick and Graham).; Dr. Jessica H. Lewis, Chapel Hill, N. C., arranged for our study of patients D. H. and R. S., and Drs. R. W. Coons and R. L. Rosenthal, New York, arranged for the study of patients V. M and B. Y., respectively.

JAMA. 1954;154(6):481-486. doi:10.1001/jama.1954.02940400019005
Abstract

Recent studies have shown that hemophilia, even if severe and classical in type, may be easily confused with other hemorrhagic states. Severe hemorrhagic manifestations, including repeated hemarthroses, a family history suggesting a sex-linked recessive inheritance, and laboratory findings, such as a long clotting time, normal prothrombin time, and delayed prothrombin utilization, may all be present; yet the disease may not be true hemophilia. On the other hand, it has been shown that hemophilia may be so mild that the diagnostic procedures in common use are inadequate for diagnosis.

In the last fewyears many cases of hemophilia-like disease, different from either the severe or mild forms of hemophilia, have been described. As in hemophilia, there is a bleeding tendency from childhood, and often there are other bleeders in the family. The clotting defects shown by these patients are of several different types. They resemble hemophilia in that there is ineffectual conversion

First Page Preview View Large
First page PDF preview
First page PDF preview
×