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May 13, 1950


Author Affiliations

Banting and Best Department of Medical Research, University of Toronto, Canada.

JAMA. 1950;143(2):198. doi:10.1001/jama.1950.02910370048023

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To the Editor:—  In a Current Comment, in The Journal, January 28, page 262, mention is made of experiments in which dietary hypercholesteremia in the rabbit resulted consistently in the production of atherosclerosis. However, in the alloxan diabetic rabbit this effect was not produced. This work was difficult to reconcile with the higher incidence of atherosclerosis which occurs in human diabetes, until the publication of J. B. Firstbrook (Science111:31 [Jan. 13] 1950), which was not included in your comment, possibly because it had not yet appeared when your article was being prepared. In normal rabbits he has demonstrated the importance of differences in the change of weight during the experiment on the production of atherosclerosis. If the food intake of rabbits fed cholesterol was diminished, the incidence of atherosclerosis was also diminished. Dr. Firstbrook's work makes it appear that the low incidence of experimental atherosclerosis in rabbits rendered

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