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February 8, 1947


Author Affiliations

San Antonio, Texas

JAMA. 1947;133(6):393-394. doi:10.1001/jama.1947.62880060011007b

Benadryl, beta-dimethylaminoethyl benzhydryl ether hydrochloride, became available to the public in March 1946. Since that time it has become widely used for various types of allergy, the demand not infrequently exceeding the supply. While side reactions to the drug are common, definite toxic or allergic reaction has not previously been reported, although 3 possible cases of spontaneous asthma resulting from its use were reported by Waldbott,1 and a vasospastic condition involving the fingers of one hand was reported by Friedlander and Feinberg,2 but the condition was thought to be coincidental. Side reactions are normally expected, despite the fact that they are sometimes severe enough to necessitate discontinuance of further treatment. Side reactions previously reported are: drowsiness, sleepiness, nervousness, dryness of the upper respiratory passages, weakness, fatigue, ataxia, facial edema, urinary frequency, nausea, epigastric distress, bad taste, a tendency to bleed, a sense of relaxation, tingling of the extremities

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