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February 20, 1954


JAMA. 1954;154(8):681. doi:10.1001/jama.1954.02940420043016

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Little is known concerning so-called epidemic nausea, vomiting, and diarrhea. The general opinion appears to favor a viral etiology, chiefly because no known specific primary enteric pathogens have been recovered from the patients affected. Reimann and associates1 administered to experimental subjects fresh, filtered broth garglings and suspensions of diarrheal stools from patients sick with epidemic diarrhea, nausea, and vomiting. The nebulized filtrates were inhaled in a closed container. Within a few days, in many of the experimental subjects malaise, headache, abdominal discomfort, nausea, vomiting, and diarrhea developed. Some had a nasopharyngitis. The investigators concluded that the noxious agent was a filtrable virus that was air borne and entered the body through the respiratory tract. It was present in the oropharynx and intestinal tract.

Felsen2 postulated the gastrointestinal manifestations to be focal and nonspecific. The primary viral agent is extra-enteric and probably located in the respiratory tract. It is,

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