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December 3, 1932


JAMA. 1932;99(23):1953-1954. doi:10.1001/jama.1932.02740750055017

The formation of red blood cells outside the bone marrow has been observed under experimental conditions in the laboratory animal. It has been noted not only in remnants of embryonic blood-forming tissue in the new-born but also in certain morbid processes involving the adult human being. Local formation of ectopic erythroblastic tissue has been seen in pathologic calcification and ossification involving the lungs, arteries, muscle tissue and lymph nodes. Extramedullary foci of bone marrow in the form of nodules have also been observed in the kidney and the suprarenals. Extensive involvement of various organs has been noted with generalized pathologic changes in the body resulting from infections, intoxications and diseases of the blood-forming organs. In many instances the significance of these changes is not clear. For the most part, extensive extramedullary erythropoiesis has been regarded as a compensatory process following interference with normal red blood cell formation. This has been

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