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June 10, 1950

TREATMENT OF PNEUMONIA IN CHILDREN WITH A SINGLE INJECTION OF REPOSITORY PENICILLINA Study of Height and Duration of Penicillin Levels

Author Affiliations

Baltimore

From the Harriet Lane Home of the Johns Hopkins Hospital and the Department of Pediatrics, Johns Hopkins University School of Medicine.

JAMA. 1950;143(6):532-535. doi:10.1001/jama.1950.02910410018004
Abstract

The use of penicillin in the treatment of pneumonia in outpatients was made practical by its suspension in oil and beeswax. Although the use of such a preparation in children was satisfactory,1 daily injections were necessary and in adults reactions were frequent.2 Therefore, following the report of Tillett, Cambier and McCormack,3 and later the experimental work of several investigators,4 a twelve hour schedule of aqueous penicillin intramuscularly was chosen for use in the pediatric outpatient department of this hospital. For the past two years such a schedule has been used successfully. It has, however, posed a twofold problem: first, the inconvenience to the parents and possible harm to the patient of repeated dispensary visits; second, the increased burden on the nursing and administrative facilities of the outpatient department. For these reasons, a study of the effectiveness of a new repository penicillin giving therapeutic levels for several

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