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June 10, 1950


JAMA. 1950;143(6):570. doi:10.1001/jama.1950.02910410056022

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To the Editor:—  An aspect of pituitary adrenocorticotropic hormone (ACTH) therapy which seems to have escaped attention is the relationship of the pituitary adrenal axis to fat metabolism and to fatty infiltration of the liver. There is a considerable amount of evidence at hand to indicate that the pituitary adrenal axis is involved in fat metabolism and the production of fatty infiltration of the liver. There are few references in the literature concerning the relationship of the hormone to lipid metabolism and fatty infiltration of the liver.Baker, Ingle, Li and Evans (Am. J. Anat.82: 75, 1948), using a histochemical technic, have demonstrated in rats given high carbohydrate diets that after 10 to 21 days of daily injections of ACTH the liver shows considerable lipid infiltration. This is manifested by a vacuolation of the hepatic cells and a reduction in cytoplasmic ribonucleoprotein. Li, Simpson and Evans (Endocrinology44:71,

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