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June 17, 1950

ANTISPASMODIC DRUGSEvaluation of Their Effects on the Motor Activity of the Upper Portion of the Small Intestine in Man

Author Affiliations


From the Medical Services, Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School.

JAMA. 1950;143(7):627-630. doi:10.1001/jama.1950.02910420015005

The purpose of this communication is to present in summary form our results of testing the effects of a number of commonly used antispasmodic drugs on the motility of the upper portion of the small intestine in man. The agents have been administered in the usual therapeutic doses to healthy young adults, and their action has been recorded by a multiple-balloon water manometer system. In spite of the numerous studies on this subject, the results have often been conflicting.1 The discrepancies have in part been due to differences in experimental methods and technics and to inadequate control observations. Our studies have been an attempt to minimize the variables due to these factors by employing standardized testing procedures and observing changes in motility over long test periods following the administration of placebos. Perhaps an additional variable has been more adequately controlled by using as experimental subjects persons with normal intestinal

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