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September 9, 1939

TRANSPLANTATION OF ADRENAL CORTEX FOR ADDISON'S DISEASE

JAMA. 1939;113(11):1034-1035. doi:10.1001/jama.1939.02800360048015
Abstract

The feasibility of successful transplantation of the adrenal gland in animals has been demonstrated by a number of investigators. The rat, according to Jaffe,1 offers excellent opportunities for such a study. In his experience successful transplants were obtained in at least 80 per cent of attempts. The process of regeneration was completed in from three to four weeks, after which time the transplant grew and reached the size of a normal gland. Jaffe and Plavska's autoplastic transplants in guinea pigs maintained their animals for months after the removal of the second main gland. These results appear to be conclusive of function when the results are compared with the results for guinea pigs whose adrenals were removed and in which transplants were not done; these survived three or four days. Elliott and Tuckett2 observed that the subcutaneous tissues of guinea pigs are peculiarly sensitive to adrenal grafts, which produce

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