The significance of the recent excellent and timely article by Ratner and Untracht1 relating to allergy to influenza A and B vaccine in children, in which they emphasize the importance of testing patients for sensitivity to the egg protein products in the vaccine, is borne out by a recent case in which death occurred after a subcutaneous injection of the recommended dose of influenza vaccine in a child. Because this case emphasizes Ratner and Untracht's warning, it is felt that it should be reported promptly in order to establish the very real danger that exists in the administration of influenza and other vaccines prepared from cultures grown in chick embryo without previously observing the precaution of intradermal skin testing with the undiluted vaccine to determine whether hypersensitivity exists.
REPORT OF CASE
History and Course.—
J. H., a white girl aged 3½ years, received a subcutaneous injection of 0.5
CURPHEY TJ. FATAL ALLERGIC REACTION DUE TO INFLUENZA VACCINE. JAMA. 1947;133(15):1062–1064. doi:10.1001/jama.1947.62880150001007