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April 17, 1954

Diagnosis and Localization of Brain Tumors: A Clinical and Experimental Study Employing Fluorescent and Radioactive Tracer Methods

JAMA. 1954;154(16):1395. doi:10.1001/jama.1954.02940500075035

This interesting monograph presents in detail the author's efforts at localizing brain tumors by substances injected into the blood stream, which lodge selectively in the tumors and are detected by various means. Most of these efforts were futile, but in two instances a certain measure of success was achieved. The first of these was the use of fluorescein, which is detected in the tumor tissue at the operating table when the tumor tissue is exposed to ultraviolet light. Of 109 tumors examined in this way, 101 fluoresced. Inflammatory tissue, cerebral cortex damaged by the application of high frequency coagulating electric current, and cerebral tissue damaged in other ways may also fluoresce. The second method is the use of suitable apparatus for the detection of radioactivity from a concentration of various radioactive substances in brain tumors. The principal substances so used were radioactive diiodofluorescein and radioactive iodinated human serum albumin. Unfortunately,

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