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May 10, 1947


Author Affiliations

Ann Arbor, Mich.

From the Department of Internal Medicine, University of Michigan Medical School.

JAMA. 1947;134(2):130-138. doi:10.1001/jama.1947.02880190018006

Harris,1 in 1924, was the first to emphasize the fact that a fairly characteristic group of symptoms experienced by some persons is the result of a spontaneous fall of the blood sugar to hypoglycemic levels. He suggested that this clinical syndrome be called hyperinsulinism. In the ensuing years there has been developed a large reservoir of detailed knowledge regarding various aspects of spontaneous hypoglycemia. From the point of view of the clinician, the following aspects of this information are of prime importance.

  1. The Multiplicity of Causes of Spontaneous Hypoglycemia.—Spontaneous hypoglycemia must be regarded merely as a manifestation of an abnormality of carbohydrate metabolism, the cause of which may be one of a variety of diseases. Proof that a group of symptoms complained of by the patient is associated with an abnormally low level of sugar in the blood and that these symptoms can be quickly relieved by the

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