May 10, 1947

Current Comment

JAMA. 1947;134(2):148. doi:10.1001/jama.1947.02880190036013

FATAL AUDIOGENIC SEIZURES IN MICE  The term "audiogenic seizure" is employed for a pattern of behavior in rats and mice which is produced by auditory stimulation, such as an air blast, Galton whistle or the jingling of keys. The seizure is characterized by frenzied running, terminating in convulsions. In a report on this subject by Hall1 audiogenic seizures were observed in mice following ringing of a bell inside a wash tub. Two strains of inbred mice were observed with great differences in reaction between the strains. Two mice of the more highly reactive strain died following the production of convulsions by auditory stimuli. Evidence that susceptibility to audiogenic seizures is inheritable had been previously compiled. Hall's experiments, however, appear to be the first in which lethal effects were observed from auditory stimulation. The suggested possibility that there may be a wide variation in inherent susceptibility to noise in human

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