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May 10, 1947


JAMA. 1947;134(2):206-207. doi:10.1001/jama.1947.02880190094024

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To the Editor:—  In your correspondence of March 15 you publish a statement of Dr. Ludwik Gross about which I should like to comment. The first intracutaneous implantation of tumors in rats which established immunity against that particular tumor was performed by me 1927 at the University Institute for Cancer Research in Berlin (Knopf, Eduard: Ztschr. f. Krebsforsch.25:64).A therapeutic experiment in a case of inoperable and radio-resistant uterine cancer was performed at the Jewish Hospital in Berlin in 1930. The results were regression of the original tumor, changes in the histologic structure of the transplant and great improvement in the subjective symptoms of the patient lasting almost to the day of her death of circulatory failure (Knopf, Eduard, ibid.32:305).The experiments conducted by Besredka and Gross in 1935 confirmed my observations in part. These authors implanted tumor particles intracutaneously into mice and thus induced immunity

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