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The first edition of this work, which appeared in 1923, has been an invaluable summary and source book for all students of general physiology. The analytic investigation of vital processes is advancing rapidly, but the way in which the simpler processes of inorganic physics and chemistry are combined to yield the properties of living substance remains obscure. When the materials and energies of the surrounding world unite to constitute the organism, new qualities and modes of activity come into existence. The biologic interest, then, centers in the conditions and patterns of this combination and in the nature of the resulting unity; that is, in the integrative functions. It is to these that attention is especially directed in this work. "And the problem of integration resolves itself largely into the problem of the conditions under which protoplasmic processes, although spatially separated, mutually influence one another." Protoplasmic transmission is systematically reviewed, with
Protoplasmic Action and Nervous Action.. JAMA. 1932;99(25):2139. doi:10.1001/jama.1932.02740770069039