May 31, 1947


Author Affiliations

Richmond, Va.

From the Allergy Service, Medical College of Virginia.

JAMA. 1947;134(5):454-455. doi:10.1001/jama.1947.72880220001008

Granulocytopenia is believed not to have been described hitherto among the untoward side effects of tripelennamine hydrochloride, "pyribenzamine" (N. N. R.) (N' pyridyl-N' benzyl-N-dimethylethylenediamine hydrochloride), therapy.

REPORT OF CASE  A widow aged 73, whose general health had always been excellent, was first seen in 1942 for a vulvovaginitis. She was again seen on Sept. 23, 1946 for an urticaria of seven weeks' duration. Put on a dosage of 200 mg. of "pyribenzamine" daily, she showed an immediate improvement of symptoms. She was hospitalized on Oct. 10, 1946 for environmental and dietary trials. The etiology of the urticaria was not determined by the initial or subsequent investigations. The patient was discharged on Oct. 29, 1946 with the urticarial outbreaks improved but continuing. At this time examination of her blood revealed a count of 5,700 leukocytes, with a differential of polymorphonuclear neutrophils 74 per cent; lymphocytes 22 per cent, and monocytes 4

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