May 31, 1947

Current Comment

JAMA. 1947;134(5):458. doi:10.1001/jama.1947.02880220042014

LATE RESIDUALS OF INFECTIOUS HEPATITIS  An estimated 90 to 95 per cent of patients with acute infectious hepatitis appear to recover entirely within a period of two to three months. Klatskin and Rappaport1 have attempted to determine the incidence of residuals in a large group of patients presumably recovered from this disease. The studied group consisted of 217 persons presumably cured of infectious hepatitis, of whom 47 had symptoms, 59 had an enlarged liver and 41 had evidence of impaired liver function—a total of 108, eliminating duplications, or about 50 per cent of the cases. The significant symptoms were right upper quadrant pain and fat intolerance. Structural changes were not established, though the evidence suggests that the residuals mentioned indicate a disturbance of the liver. Good health and full activity over long periods— the time varying from two months to twenty-seven years —were compatible with these changes. The severity of

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