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July 22, 1950

The Eosinophil Count in Health and in Mental Disease: A Biometrical Study

JAMA. 1950;143(12):1125. doi:10.1001/jama.1950.02910470085035

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This is a detailed study of the number of eosinophils in health and disease. The literature on the subject is reviewed under the headings of physiology and pathology, and personal observations on 150 normal persons and 402 psychiatric patients are analyzed. In the neuroses and in schizophrenias the variations were equivocal, with a possible tendency to increased values in the psychoses. In the manic-depressive psychoses, the lowest values were noted in the ill patients and higher values than normal in the cured patients. An increase in the number of eosinophils was of prognostic value. There was a fall in the number of eosinophils in epileptic attacks and migraine.

A bibliography of 667 articles is appended. The book is an excellent review of the problem of the eosinophil and should serve as a starting point for future work on the nature of this colorful cell.

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