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July 29, 1950

Coagulation, Thrombosis, and Dicumarol with an Appendix on Related Laboratory Procedures

JAMA. 1950;143(13):1217. doi:10.1001/jama.1950.02910480089030

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Abstract

In this book, the authors attempt to acquaint the reader with current theoretic and practical knowledge concerning thrombosis, hemorrhage and anticoagulant therapy. It contains a modest presentation of the "factors and drugs which influence coagulation and thrombosis, and the influence of dicumarol® anticoagulant activity."

The discussion of coagulation and thrombosis is in outline form and, as such, is rather well presented and concise. The known characteristics of fibrinogen and the role of thromboplastin are dealt with briefly but sufficiently to indicate present conceptions of their roles in thrombosis.

The first part of the discussion of dicumarol® is well done. The story of its discovery and isolation by Link is excellent. However, the discussion of the clinical investigation and the statistical evaluation of the results of treatment are too inadequate to be important. The technic of dicumarol® therapy as used by Shapiro is outlined. Shapiro apparently does not believe that a

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