June 21, 1947


Author Affiliations


From the Medical and Pathological Departments of the Philadelphia General Hospital.

JAMA. 1947;134(8):670-673. doi:10.1001/jama.1947.02880250018005

The term "alcoholic cirrhosis" is at once misleading. It implies that alcohol produces a certain characteristic type of cirrhosis. This, of course, is not true. There is no gross pathologic or histologic type of cirrhosis that can be identified as alcoholic in origin. Alcoholic cirrhosis is generally accepted as being synonymous with portal cirrhosis, although the latter condition is frequently found in children and adults who have not even remotely had anything to do with alcohol, and despite the fact that in the great majority of alcoholic addicts, as far as is known, cirrhosis does not develop.

It is just a hundred years since Rokitansky stated that "granular liver is one of the most important, though in many respects and especially in reference to its pathogeny, one of the most enigmatical affections of the liver." While some progress has been made in recent years in the study of the pathogenesis

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