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Article
June 21, 1947

NEW METHODS OF THERAPY IN CIRRHOSIS OF THE LIVER

Author Affiliations

Los Angeles

From the Department of Internal Medicine, College of Medical Evangelists.

JAMA. 1947;134(8):673-679. doi:10.1001/jama.1947.02880250021006
Abstract

Cirrhosis of the liver is no longer a hopeless, incurable disease destined to progress until death intervenes. Recent reports1 are rapidly accumulating evidence which shows that many patients with hepatic cirrhosis can improve, or recover as judged by clinical observations and laboratory tests, after treatment by the Patek regimen,1a, b with choline or with choline and cystine.1i I have reported elsewhere a detailed analysis of the results of treatment in cirrhosis of the liver in a series of 62 patients studied at two year intervals1j over an eight year period of time. In this present paper the results and basis for the treatment of choice in cirrhosis are described and offered for trial by others.

METHODS OF TREATMENT  The treatment which I have adopted consists in the administration of methionine, 2 Gm. daily; choline chloride, 2 Gm. daily, a special liver extract prepared by the filtration and

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