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August 5, 1950

The Diagnosis and Treatment of Adrenal Insufficiency

JAMA. 1950;143(14):1292. doi:10.1001/jama.1950.02910490070027

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This factual and valuable monograph traces the historical development of the theory and treatment of adrenocortical insufficiency. The information contained has been accumulated from more than 200 case studies observed by the senior author. The text reviews the physiologic functions of the adrenal cortex in relation to the chemical structure of the isolated adrenocortical hormones. It briefly describes the varieties of adrenocortical insufficiency which may be encountered in the clinic. Addison's disease is more exhaustively considered. The signs and symptoms, laboratory findings and various screening and tolerance tests are described and discussed in fair detail. The diagnostic program employed by the authors, the differential diagnosis, treatment and management of the patient are also presented.

This monograph is a valuable reference text containing basic information for the student and practitioner.

It is unfortunate that cortisone as a therapeutic agent in hypoadrenalism is not considered.

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