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August 12, 1950

INFECTIOUS MONONUCLEOSIS

JAMA. 1950;143(15):1360. doi:10.1001/jama.1950.02910500062023

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Abstract

To the Editor:—  In a recent paper entitled "Aureomycin in Infectious Mononucleosis" by Seifert, Chandler and Van Winkle (The Journal142:1133 [April 15] 1950) is contained the statement "We do not subscribe to the belief of Davidsohn that there must be a positive heterophil titer after adsorption on guinea pig kidney before the diagnosis can be made." I have never made a statement, in writing or otherwise, justifying the belief attributed to me in the article. As a matter of fact, I expressed myself to the contrary and have recognized the existence of two forms of infectious mononucleosis: a seropositive and seronegative (The Journal108:289 [Jan. 23] 1937).I do believe that the differential test for infectious mononucleosis makes it possible to recognize some cases of the disease which could not be recognized without it, especially when the presumptive test (heterophile antibody test) shows a titer of 1:

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