Anemia of pregnancy appears to be a comparatively rare disease. A search of the literature available reveals the fact that very few cases have been reported, and among the few there seems to be considerable variation with regard to both the clinical symptoms and the appearance of the blood pictures.
Rowland1 divides these cases into two groups: hematologically primary and hematologically secondary. He reported two cases in 1924 and has reported four cases since that time. Larrabee2 has reported seventeen cases of anemia of pregnancy with the blood picture of a secondary anemia. A palpable spleen was present in two cases. There were two atypical cases in this series, one of which cleared up only after splenectomy, repeated blood transfusions having failed. Birdsong, Hulbert and Welchell have reported one case of splenic anemia and pregnancy.
The symptoms are described by Rowland as follows: The onset of the disease
Hamlin LE. ANEMIA OF PREGNANCY WITH ENLARGEMENT OF THE SPLEEN. JAMA. 1932;99(27):2264–2265. doi:10.1001/jama.1932.27410790001010