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Mammary Cancer and Uterine Fibroids.
—A study of the association of mammary cancer and uterine fibroids has been carried on by Funck-Grentano and J. De Brux. Such an association is not common. The fact that the same pathogenic factors can produce both conditions should direct attention to those factors of endocrine origin and to clinical and therapeutic applications. Experimentally, the estrogens can produce mammary cancer in mice and fibrous tumors in guinea pig and rabbit uteri. Mammary cancer is frequently encountered in a woman who has shown biological, as well as clinical, signs of hyperfolliculinism. In 1948, Rudler reported on a 35-year-old woman in whom these two conditions developed after intensive treatment with estrone (Folliculin). In men, mammary cancer has been observed after treatment with large doses of estrogens for cancer of the prostate. The efficacy of therapy with androgens in woman is further evidence of the causal part played
FRANCE. JAMA. 1954;155(8):771-772. doi:10.1001/jama.1954.03690260063022