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August 19, 1950

MYELOID METAPLASIA

Author Affiliations

Chicago

From the Department of Medicine, University of Chicago. Supported in part by a grant from the American Cancer Society.

JAMA. 1950;143(16):1390-1396. doi:10.1001/jama.1950.02910510008002
Abstract

Myeloid metaplasia is a clinical and pathologic syndrome of varied cause which is characterized by the constant occurrence of extramedullary hematopoiesis in the spleen and almost always in the liver, splenomegaly and usually hepatomegaly, and an anemia with immature red and white cells in the peripheral blood. Because of its resemblance to leukemia it has been frequently diagnosed as such,1 and even today there is a difference of opinion concerning its relation to leukemia.2 As a result of this confusion it has been described under at least twenty-five different names.3 Many of the cases of myeloid metaplasia reported in the literature were diagnosed only at autopsy or at splenectomy4; in others, a diagnosis of sclerosis of the marrow was made but the presence of myeloid metaplasia of the liver and spleen was not proved,5 which is significant because myelosclerosis may exist without myeloid metaplasia.6

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