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August 19, 1950

HYPERVITAMINOSIS A

JAMA. 1950;143(16):1417. doi:10.1001/jama.1950.02910510035015
Abstract

The paucity of the reports on the occurrence of the syndrome of hypervitaminosis A, in the opinion of Fried and Grand,1 is probably due to lack of recognition rather than to its actual incidence. Josephs2 in 1944 reported one instance of hypervitaminosis A in man, Toomey and Morissette3 in another in 1947 and Rothman and Leon4 in 2 more. Fried and Grand report the occurrence of hypervitaminosis A in an infant 16 months old and in another 2 years old. Both presented symptoms and characteristic roentgenographic bone changes, elevated vitamin A levels in the blood serum, a history of excessive intake of vitamin A over a prolonged period and a gradual complete recovery after withdrawal cf vitamin A. Clinically, the syndrome is characterized by anorexia, loss of weight, irritability, low grade fever, pruriginous rash, sparseness of hair, hepatomegaly and tenderness over the long bones. The storage

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