[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.166.74.94. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
June 26, 1954

LIPOPROTEIN STUDIES IN DIABETICS WITH ARTERIOSCLEROTIC DISEASE

Author Affiliations

Brooklyn

From the Diabetic Research Laboratory and Medical Services, Maimonides Hospital, and the Department of Medicine, State University of New York, College of Medicine.

JAMA. 1954;155(9):814-817. doi:10.1001/jama.1954.03690270010004
Abstract

While the pathogenic mechanism responsible for the development of human arteriosclerosis still remains obscure, certain dominant features stand out as playing a role in the development of this morbid condition. Intramural bleeding with resultant inflammatory changes accompanied by deformity of the arterial coats and encroachment on the lumen appears to be one established feature of arteriosclerosis.1 Alterations in the metabolism of cholesterol with an abnormal accumulation of various components of lipids and lipoproteins appear also to play an important part in the development of this disease.2 The higher content of cholesterol in arteriosclerotic coronary arteries makes it necessary to seriously consider a derangement in cholesterol metabolism as a significant factor in atherogenesis.3 However, whether these abnormal accumulations of lipids represent etiological factors or are a biological accompaniment of arteriosclerotic disease has not been established. Certainly the experimental attempts to induce atherosclerosis in animals by means of increasing

First Page Preview View Large
First page PDF preview
First page PDF preview
×