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August 26, 1950


Author Affiliations


From the Department of Medicine, University of Chicago. Dr. McCullogh is also fro mthe Microbiological Institute of the National Institutes of Health, Public Health Service, Bethesda, Md.

JAMA. 1950;143(17):1473-1474. doi:10.1001/jama.1950.02910520015006

A relation between brucellosis and multiple sclerosis has recently been postulated by Kyger and Haden.1 They reported a high incidence of cutaneous sensitivity to Brucella antigens in patients with the diagnosis of multiple sclerosis. In 118 patients, results of intradermal tests with killed Brucella organisms were reported as positive in 115. The possibility of multiple sclerosis being etiologically related to brucellosis was proposed largely on the basis of these findings. Widespread interest has been stimulated by this implied relation. In several instances which have come to our attention, patients with multiple sclerosis have been treated by methods believed to be useful in brucellosis. A further investigation of a possible relation between these two diseases seemed desirable.


Subjects.—  Fifty-two patients with the diagnosis of multiple sclerosis were studied for evidence of brucellosis or of previous exposure to Brucella. The diagnosis of multiple sclerosis had been established by

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