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Rhinitis medicamentosa is a condition frequently associated with allergy or sinusitis. Recently, however, there have been an increasing number of unusually severe cases associated with nervous manifestations following excessive self medication with naphazoline hydrochloride ("privine hydrochloride" N. N. R.).
REPORT OF CASES
A healthy man aged 28, who had been well until four months before, began using "solution privine hydrochloride 0.1 per cent" for a cold at the recommendation of a friend. His stuffiness became worse until he was using about 2 ounces (59 cc.) a week. He had lost 20 pounds (9.1 Kg.), was unable to sleep and was so nervous that he thought he was having a breakdown. Examination of the nose showed the turbinates to be grossly swollen; they were the dead gray color and the consistency of bubble gum. They could not be shrunk even by a mixture of cocaine hydrochloride and epinephrine ("adrenalin"
MERTINS PS. EXCESSIVE SELF MEDICATION WITH NAPHAZOLINE HYDROCHLORIDE ("PRIVINE HYDROCHLORIDE"). JAMA. 1947;134(14):1175. doi:10.1001/jama.1947.72880310002008a