The majority of serious infections commonly encountered in the United States at the present time are amenable to treatment with chemotherapeutic agents. New antibiotics have appeared so rapidly, however, that difficulty is often experienced in selection of the proper agent and dosage for a specific patient. The present discussion deals with recent developments in this rapidly changing field, with emphasis on the relation of the various antibiotics to one another and to the sulfonamides.
With the introduction of aureomycin, chloramphenicol (chloromycetin®) and terramycin, indications for the sulfonamides are becoming ever more restricted. There are only three commonly encountered conditions in which sulfonamides may still be regarded as the drug of choice, namely, uncomplicated urinary tract infections, bacillary dysentery and meningococcic meningitis. Sulfonamides are also often administered in conjunction with penicillin or other agents in the treatment of certain severe infections, such as pneumococcic meningitis. Triple sulfonamide mixtures, which reduce
KIRBY WMM. RECENT TRENDS IN ANTIBIOTIC THERAPY. JAMA. 1950;144(3):233–236. doi:10.1001/jama.1950.02920030021008