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September 13, 1947


Author Affiliations

Winston-Salem, N. C.

From the Departments of Pediatrics and Urology of the Bowman Gray School of Medicine of Wake Forest College and the Pediatric Service of the North Carolina Baptist Hospital.

JAMA. 1947;135(2):93-94. doi:10.1001/jama.1947.62890020005007c

Since we are now entering a new season of increased incidence of poliomyelitis, this preliminary report is being made regarding the use of furfuryl trimethylammonium iodide ("furmethide") for one of the complications of this disease, paralysis of the bladder. The bladder is involved in 10 to 20 per cent of all patients with poliomyelitis, with more involvement in adults than in children. Usually this is manifested by distention and inability to void, but overflow dribbling may occur, and occasionally there may be hyperirritability of the vesical neck with frequency and dysuria. This disability may be overcome in some patients with the aid of hot applications to the area of the bladder and other nonspecific measures. However, many patients need to be catheterized one or more times before spontaneous voiding reappears, although eventually all do recover.

During the 1944 poliomyelitis epidemic in North Carolina we were again impressed with the desirability

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