One of the most impressive results in the treatment of tuberculosis in man by streptomycin has been obtained following its use in draining tuberculous sinuses.
Eleven Negro patients and 1 white patient, the majority of whom had multiple, draining, tuberculous, cutaneous sinuses, have been treated with streptomycin in the Veterans Administration Hospital at Oteen, N. C. There were 60 draining sinuses in the 12 patients reported in this series. The average length of time these sinuses existed prior to the institution of streptomycin therapy was twenty-four months. Treatment was started on 9 patients about July 1. 1946. In the other 3 patients it was initiated during the last week in September 1946. All but 2 of the patients had draining sinuses which originated in bone. In 1 of the 2 a sinus developed following laparotomy, and the other had several perineal sinuses originating in the ischiorectal area. All the cases
BROCK BL. STREPTOMYCIN IN THE TREATMENT OF DRAINING TUBERCULOUS SINUSES. JAMA. 1947;135(3):147–149. doi:10.1001/jama.1947.02890030015005