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September 30, 1950

Experimental Anaphylactic Iridocyclitis

JAMA. 1950;144(5):436. doi:10.1001/jama.1950.02920050076053

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Abstract

Experiments on the production of iridocyclitis in albinotic rabbits by the injection of foreign serum and egg albumin are described in detail, and interesting and provocative conclusions are drawn. Injection of a small quantity (0.1 cc.) of these substances into the vitreous of healthy rabbits produced a reaction which the author designates as primary anaphylactic iridocyclitis. Subsequent intravenous or subcutaneous injections of the homologous antigen will result in a secondary anaphylactic iridocyclitis. Many ramifications of the subject have been investigated in a thorough manner, including what the author terms "sympathetic anaphylactic iridocyclitis," in which it is shown that an antigen present in one eye affects the uveal cells in the opposite eye.

In view of contemporary theories concerning the cause of iridocyclitis in the human, the experiments described are of considerable interest and may point to a better understanding of the pathogenesis of inflammatory diseases of the uveal tract. The

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