This report concerns a case of gumma of the vagina. Syphilis of the vagina is not common, especially the gummatous lesion. The history of syphilis probably begins with Ambroïse Paré (1510-1590) who, according to Pusey, employed a vaginal speculum to study the vaginal and uterine lesions of venereal disease. The resistance of the squamous epithelium of the vagina to syphilitic infection and the coincident biologic reasons have been the subject of considerable comment from numerous syphilologists.
According to Gellhorn and Ehrenfest,1 the literature of Lancereaux (1868) does not contain any positive records of tertiary manifestations of syphilis of the vagina, which must be rarer than the exceptional primary and secondary lesions.
In 1877 Birch-Hirschfeld described a case of diffuse gummatous perivaginitis. Neumann up to 1896 had seen only 3 cases of vaginal gummas. Oppenheim2 in 1908 described a syphilitic tertiary ulcer of the vagina. The most recent record
REICH WJ, NECHTOW MJ. GUMMA OF THE VAGINA. JAMA. 1947;135(6):347–348. doi:10.1001/jama.1947.62890060005007