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October 11, 1947

SENSITIZATION TO THE PRESSOR ACTION OF EPINEPHRINE ("ADRENALIN")A Warning Concerning the Use of Epinephrine as an Antidote After the Administration of Tetraethyl Ammonium Chloride

Author Affiliations


From the Research Division of the Cleveland Clinic Foundation, Cleveland.

JAMA. 1947;135(6):348-349. doi:10.1001/jama.1947.62890060006007a

The recent widespread interest in the action of tetraethyl ammonium ion as the result of the work of Acheson with Moe1 and Pereira2 in demonstrating its selective blocking of transmission of impulses across sympathetic ganglions has led to its clinical trial in a wide variety of vascular disease. We,3 as well as Lyons and associates, 4 have been particularly interested in its action in hypertensive patients, and it is with these that this communication is concerned. Epinephrine ("adrenalin" N. N. R.) has been recommended as the antidote of choice after excessive doses of tetraethyl ammonium chloride. Acheson and Moe1 have shown that in cats with spinal block induced by this drug the response to epinephrine was at least unaffected.

During the course of experiments to determine the effect of tetraethyl ammonium chloride on the blood pressure of hypertensive dogs, there was occasion repeatedly to test the

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