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October 7, 1950

Studies on Lipids in the Nervous System with Special Reference to Quantitative Chemical Determination and Topical Distribution

JAMA. 1950;144(6):507-508. doi:10.1001/jama.1950.02920060069044

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Gunnar Brante of the Institute of Medical Chemistry, University of Upsala, Sweden, critically examined modern concepts of lipid chemistry and modern micromethods for separating and determining individual lipids in biologic materials prior to making a thorough, careful study of the topical distribution of lipids in the nervous systems of man, cow, horse, rabbit, rat and lobster. He paid attention to the lipids in axons and in the myelin sheath. The results of his work are given here in English.

The substances determined routinely were: total lipids, lipid phosphorus, phosphorus released by mild treatment with alkali and acid, glycerin, choline, choline in lecithin, 2-aminoethanol, amino acids, hexoses, inositol and cholesterol. From the results of these analyses are obtained the total lipids, phospholipids, free and total cholesterol, cerebrosides, lecithins, cephalins A and B, sphingomyelins, diglycerides, ethanolamine phospholipids, serine phospholipids and "diphosphoinositide."

Normal prenatal and postnatal development of the central nervous system was

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