[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.166.74.94. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Other Articles
October 7, 1950

Studies on Lipids in the Nervous System with Special Reference to Quantitative Chemical Determination and Topical Distribution

JAMA. 1950;144(6):507-508. doi:10.1001/jama.1950.02920060069044

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

Gunnar Brante of the Institute of Medical Chemistry, University of Upsala, Sweden, critically examined modern concepts of lipid chemistry and modern micromethods for separating and determining individual lipids in biologic materials prior to making a thorough, careful study of the topical distribution of lipids in the nervous systems of man, cow, horse, rabbit, rat and lobster. He paid attention to the lipids in axons and in the myelin sheath. The results of his work are given here in English.

The substances determined routinely were: total lipids, lipid phosphorus, phosphorus released by mild treatment with alkali and acid, glycerin, choline, choline in lecithin, 2-aminoethanol, amino acids, hexoses, inositol and cholesterol. From the results of these analyses are obtained the total lipids, phospholipids, free and total cholesterol, cerebrosides, lecithins, cephalins A and B, sphingomyelins, diglycerides, ethanolamine phospholipids, serine phospholipids and "diphosphoinositide."

Normal prenatal and postnatal development of the central nervous system was

First Page Preview View Large
First page PDF preview
First page PDF preview
×