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October 7, 1950

The Nose: An Experimental Study of Reactions within the Nose in Human Subjects During Varying Life Experiences

JAMA. 1950;144(6):508. doi:10.1001/jama.1950.02920060070047

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The present book gives a brief discussion of the pertinent literature on nasal physiology followed by a description of extensive observations by the authors on alterations in nasal function particularly under conditions of emotional excitement. Attempts were made to quantitate the response of the nasal mucosa, and numerous graphs show the results of well controlled experiments. It is found that ischemia and pallor accompany "feelings of being overwhelmed with an abject fear or with dejection," whereas anxiety and resentment produce hyperemia, swelling, hypersecretion and even obstruction in the nose. Apparently, the autonomic discharge is different in different types of emotion as was shown earlier by the authors in their outstanding work on human gastric function. Blocking sympathetic impulses through injection of procaine hydrochloride in the stellate ganglion led to temporary hyperfunction of the nasal mucosa, whereas elimination of the parasympathetic supply caused nasal hypofunction with dry, pale and shrunken membranes.

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