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It is estimated that a bone sarcoma develops in one out of every 100,000 persons in the United States. Assuming that about 85% are of the osteogenic type, and with a current population of 160 million it is conjectured that there are roughly 1,400 persons with sarcoma in this country at any given time. The site of origin is the metaphyseal region of major long bones. The commonest sites are the lower femur, the upper humerus, and the upper tibia. The lesion is essentially one of youth, and the ratio of males to females is 5:3. There is a wide variation in the rate of growth, the degree of bone destruction, and the severity of symptoms. Pain is the earliest symptom. At first it is insidious, of a fleeting and transitory type.Later it becomes persistent and severer.
The diagnosis is established by the history, physical examination, roentgen examination, and laboratory
Strohl EL. COMMENT. JAMA. 1954;156(3):249-250. doi:10.1001/jama.1954.02950030041012a