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To the Editor:—
Following the report of the use of urethane in a patient with anaplastic carcinoma by Drs. M. J. Goodman and H. P. Lewis (J. A. M. A., Correspondence, 132:1105 [Dec. 28] 1946) a justifiable opportunity for therapeutic trial of this material presented itself in a similar case. A man aged 34, who had served without medical incident throughout the North African, Sicilian and Italian campaigns and whose past history was otherwise noncontributory, was hospitalized for progressive anorexia with loss of weight and unremitting fever. A rectosigmoid peritoneal shelf was palpated, and examination after a barium enema revealed an apparently extrinsic constricting mass in this area. Because of the clinical diagnosis of carcinoma originating in the ailmentary tract with extensive peritoneal metastasis, a laparotomy was foregone. However, biopsy of a "nova" right supraclavicular gland showed infiltration by a distinctly anaplastic epithelium, which the pathologist could not reconcile
Barnard RD. URETHANE IN ANAPLASTIC CARCINOMA. JAMA. 1947;135(7):450-451. doi:10.1001/jama.1947.02890070052022