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This exceedingly interesting monograph on the extracellular action of adenine nucleotides is an outgrowth of the authors' clinical investigations of the shock syndrome made in England in the early part of the World War II. They discovered that almost all the shock-inducing effects of fresh muscle extract, injected by routes other than the intravenous, could be ascribed to the adenosine triphosphate (ATP) which it contains and that most of the effect of fresh muscle extract, injected intravenously, could be ascribed to the adenosine triphosphate and the thromboplastin present. After these discoveries, they thoroughly studied, by pharmacologic, physiologic and biochemical technics, the biologic action of extracellular adenine nucleotides in a variety of mammals, including man. They report here in considerable detail the action of adenosine triphosphate and related compounds on the cardiovascular, respiratory and renal systems.
Among the factors investigated for their possible effect on the severity of the purine-induced shock
Biological Actions of the Adenine Nucleotides. JAMA. 1950;144(8):720. doi:10.1001/jama.1950.02920080122033