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October 28, 1950


JAMA. 1950;144(9):764-765. doi:10.1001/jama.1950.02920090038013

Since Gordon's1 report in 1934, numerous suggestions have been made as to the possible virus etiology of Hodgkin's disease. In tests made by Bostick2 of the Division of Pathology, University of California, Seitz-filtered extracts of fresh lymph nodes from patients with Hodgkin's disease were injected into the amniotic sacs of seven day old chick embryos; control injections were made with extracts of material from subjects with malignant diseases other than Hodgkin's disease. A slight lethal effect was noted in the series inoculated with the Hodgkin's disease material. Since this was continued during serial passage of the extract, it suggests a multiplication of some toxic or infectious factor, presumably a virus, in the amniotic fluid.

Further evidence of the virus nature of this amniotic factor was afterward sought by Bostick3 by application of the technic of virus antagonism. It is well known that two viruses grown or inoculated

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