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November 15, 1947


JAMA. 1947;135(11):716. doi:10.1001/jama.1947.02890110034011

Additional evidence is now available to support the concept of etiologic relation between nontuberculous benign pulmonary calcifications and a benign form of histoplasmosis. Zwerling and Palmer1 report a study of pulmonary calcifications made as a cooperative project by the National Tuberculosis Association, the United States Public Health Service and a number of schools of nursing. Histoplasmin and tuberculin skin tests and roentgenograms were available for 6,199 student nurses in eight large cities. The incidence of calcification closely paralleled a positive reaction to histoplasmin; such a parallel with positive tuberculin reactions was not apparent in the material studied. Pulmonary calcification was found in 698 nurses, of whom 494 were histoplasmin positive, 109 had positive reactions to both tuberculin and histoplasmin, 57 were tuberculin positive and 38 had negative reactions to both histoplasmin and tuberculin. Geographically the incidence of calcifications varied widely. Four times as many student nurses in Kansas City,

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